Lymphedema and obesity: Is there a link? Journal Article


Authors: Mehrara, B. J.; Greene, A. K.
Article Title: Lymphedema and obesity: Is there a link?
Abstract: Lymphedema is a chronic disorder that, in developed countries, occurs most commonly after lymph node dissection for cancer treatment. Although the pathophysiology of lymphedema is unknown, the disease is characterized histologically by fibrosis and abnormal adipose deposition. Clinical studies have provided evidence that obesity and postoperative weight gain are significant risk factors for the development of lymphedema. In fact, recent studies have shown that extreme obesity can result in markedly impaired lymphatic function and primary lymphedema. The aim of this Special Topic article is to review evidence linking obesity and lymphedema. In addition, the authors review recent studies that have analyzed the cellular mechanisms that may be responsible for this relationship, with a goal of highlighting areas of research that may have significant translational potential.
Keywords: review; obesity; lymphedema; humans; human
Journal Title: Plastic and Reconstructive Surgery
Volume: 134
Issue: 1
ISSN: 0032-1052
Publisher: Lippincott Williams & Wilkins  
Date Published: 2014-07-01
Start Page: 154e
End Page: 160e
Language: English
PUBMED: 25028830
PROVIDER: scopus
DOI: 10.1097/prs.0000000000000268
PMCID: PMC4393748
DOI/URL:
Notes: Export Date: 1 October 2014 -- Source: Scopus
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  1. Babak Mehrara
    463 Mehrara
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