Fibrosis and secondary lymphedema: Chicken or egg? Review


Authors: Kataru, R. P.; Wiser, I.; Baik, J. E.; Park, H. J.; Rehal, S.; Shin, J. Y.; Mehrara, B. J.
Review Title: Fibrosis and secondary lymphedema: Chicken or egg?
Abstract: Secondary lymphedema is a common complication of cancer treatment resulting in progressive fibroadipose tissue deposition, increased risk of infections, and, in rare cases, secondary malignancies. Until recently, the pathophysiology of secondary lymphedema was thought to be related to impaired collateral lymphatic formation after surgical injury. However, more recent studies have shown that chronic inflammation-induced fibrosis plays a key role in the pathophysiology of this disease. In this review, we will discuss the evidence supporting this hypothesis and summarize recent publications demonstrating that lymphatic injury activates chronic immune responses that promote fibrosis and lymphatic leakiness, decrease collecting lymphatic pumping, and impair collateral lymphatic formation. We will review how chronic mixed T-helper cell inflammatory reactions regulate this process and how this response may be used to design novel therapies for lymphedema. © 2019 Elsevier Inc.
Journal Title: Translational Research
Volume: 209
ISSN: 1931-5244
Publisher: Elsevier Science, Inc.  
Date Published: 2019-07-01
Start Page: 68
End Page: 76
Language: English
DOI: 10.1016/j.trsl.2019.04.001
PUBMED: 31022376
PROVIDER: scopus
PMCID: PMC7400991
DOI/URL:
Notes: Review -- Export Date: 1 July 2019 -- Source: Scopus
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  1. Babak Mehrara
    462 Mehrara
  2. Yu Sup Shin
    9 Shin
  3. Raghu Prasad Kataru
    63 Kataru
  4. Sonia Rehal
    5 Rehal
  5. Jungeun Baik
    13 Baik
  6. Hyeung Ju Park
    20 Park
  7. Itay Wiser
    6 Wiser
  8. Jinyeon Shin
    24 Shin