A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC Journal Article
| Authors: | Xiao, W.; Nardi, V.; Stein, E.; Hasserjian, R. P. |
| Article Title: | A practical approach on the classifications of myeloid neoplasms and acute leukemia: WHO and ICC |
| Abstract: | In 2022, two new classifications of myeloid neoplasms and acute leukemias were published: the 5th edition WHO Classification (WHO-HAEM5) and the International Consensus Classification (ICC). As with prior classifications, the WHO-HAEM5 and ICC made updates to the prior classification (revised 4th edition WHO Classification, WHO-HAEM4R) based on a consensus of groups of experts, who examined new evidence. Both WHO-HAEM5 and ICC introduced several new disease entities that are based predominantly on genetic features, superseding prior morphologic definitions. While it is encouraging that two groups independently came to similar conclusions in updating the classification of myeloid neoplasms and acute leukemias, there are several divergences in how WHO-HAEM5 and ICC define specific entities as well as differences in nomenclature of certain diseases. In this review, we highlight the similarities and differences between the WHO-HAEM5 and ICC handling of myeloid neoplasms and acute leukemias and present a practical approach to diagnosing and classifying these diseases in this current era of two divergent classification guidelines. © The Author(s) 2024. |
| Keywords: | adult; human tissue; myeloproliferative disorders; myeloproliferative disorder; leukemia, myeloid, acute; review; consensus; classification; pathology; acute leukemia; myelodysplastic syndrome; diagnosis; world health organization; clinical practice guideline; therapy; myelodysplastic syndromes; bone marrow tumor; acute myeloid leukemia; humans; human |
| Journal Title: | Journal of Hematology & Oncology |
| Volume: | 17 |
| ISSN: | 1756-8722 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2024-07-29 |
| Start Page: | 56 |
| Language: | English |
| DOI: | 10.1186/s13045-024-01571-4 |
| PUBMED: | 39075565 |
| PROVIDER: | scopus |
| PMCID: | PMC11287910 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Wenbin Xiao -- Source: Scopus |
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