What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms? Review
| Authors: | Attygalle, A. D.; Chan, J. K. C.; Coupland, S. E.; Du, M. Q.; Ferry, J. A.; de Jong, D.; Gratzinger, D.; Lim, M. S.; Nicolae, A.; Ott, G.; Rosenwald, A.; Schuh, A.; Siebert, R.; on behalf of the WHO 5th Edition Classifcation Project |
| Review Title: | What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms? |
| Abstract: | The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated several times. In this review, we briefly outline the cornerstones of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours on lymphoid neoplasms. As is adopted throughout the 5th edition of the WHO classification of tumors of all organ systems, entities are listed by a hierarchical system. For the first time, tumor-like lesions have been included in the classification, and modifications of nomenclature for some entities, revisions of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities are presented along with mesenchymal lesions specific to the stroma of lymph nodes and the spleen. In addition to specific outlines on constitutional and somatic genetic changes associated with given entities, a separate chapter on germline predisposition syndromes related to hematologic neoplasms has been added. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. |
| Keywords: | review; cell proliferation; lymphocyte proliferation; cytology; classification; histology; hodgkin disease; b cell lymphoma; cutaneous t cell lymphoma; peripheral t cell lymphoma; t cell lymphoma; lymphoma; world health organization; cancer classification; immune deficiency; anaplastic large cell lymphoma; who; immune dysregulation; paraprotein; stromal tumor; human; hereditary tumor syndrome; 5th edition; malignant neoplasm; lymphoproliferation; mediastinal gray zone lymphoma; aggressive b cell lymphoma; fibroblastic reticular cell neoplasm; follicular dendritic cell neoplasm; follicular large b cell lymphoma; hematolymphoid tumor; indolent small b cell lymphoma; lymph node mesenchymal tumor; mesenchymal lesion; natural killer cell lymphoma; nodal t follicular helper cell lymphoma; non nodal t cell lymphoma; spleen mesenchymal tumor |
| Journal Title: | Journal of Hematopathology |
| Volume: | 17 |
| Issue: | 2 |
| ISSN: | 1868-9256 |
| Publisher: | Springer |
| Date Published: | 2024-06-01 |
| Start Page: | 71 |
| End Page: | 89 |
| Language: | English |
| DOI: | 10.1007/s12308-024-00585-8 |
| PROVIDER: | scopus |
| PUBMED: | 38683440 |
| DOI/URL: | |
| Notes: | Source: Scopus |
