Cytogenetics and molecular genetics of myelodysplastic neoplasms Review
| Authors: | Ning, Y.; Zhang, Y.; Kallen, M. A.; Emadi, A.; Baer, M. R. |
| Review Title: | Cytogenetics and molecular genetics of myelodysplastic neoplasms |
| Abstract: | According to the 2022 World Health Organization (WHO) Classification (5th edition), the term myelodysplastic neoplasms (abbreviated MDS) has been introduced to replace myelodysplastic syndromes. MDS are a group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more of lineages, ineffective hematopoiesis, and an increased risk of progression to bone marrow failure or to acute myeloid leukemia (AML). Current NCCN guidelines and recent review articles have provided in depth discussion on the clinical diagnosis and management of MDS. This review will focus on discussion of the WHO and International Consensus Classification (ICC) updates on the role of cytogenetics and molecular genetics in the diagnosis and risk stratification of MDS. © 2023 Elsevier Ltd |
| Keywords: | gene mutation; review; molecular genetics; antineoplastic agent; cancer diagnosis; cytogenetics; patient care; myelodysplastic syndrome; world health organization; genetic disorder; cancer classification; cancer prognosis; international prognostic scoring system; human; mds diagnosis; mds genetics; mds management; mds prognosis |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-12-01 |
| Start Page: | 101512 |
| Language: | English |
| DOI: | 10.1016/j.beha.2023.101512 |
| PROVIDER: | scopus |
| PUBMED: | 38092472 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
