Ferroptosis: Biology and role in gastrointestinal disease Review
| Authors: | Escuder-Rodríguez, J. J.; Liang, D.; Jiang, X.; Sinicrope, F. A. |
| Review Title: | Ferroptosis: Biology and role in gastrointestinal disease |
| Abstract: | Ferroptosis is a form of nonapoptotic cell death that involves iron-dependent phospholipid peroxidation induced by accumulation of reactive oxygen species, and results in plasma membrane damage and the release of damage-associated molecular patterns. Ferroptosis has been implicated in aging and immunity, as well as disease states including intestinal and liver conditions and cancer. To date, several ferroptosis-associated genes and pathways have been implicated in liver disease. Although ferroptotic cell death is associated with dysfunction of the intestinal epithelium, the underlying molecular basis is poorly understood. As the mechanisms regulating ferroptosis become further elucidated, there is clear potential to use ferroptosis to achieve therapeutic benefit. © 2024 AGA Institute |
| Keywords: | signal transduction; review; nonhuman; pathophysiology; colorectal cancer; animal; metabolism; animals; cell death; gene; inflammation; pathology; immunotherapy; iron; hemochromatosis; reactive oxygen species; reactive oxygen metabolite; liver disease; virus hepatitis; gastrointestinal disease; lipid peroxidation; liver injury; gastrointestinal diseases; tumor microenvironment; mitochondrial respiration; liver fibrosis; inflammatory bowel disease; intestine epithelium; ferroptosis; cancer; humans; human; phospholipid hydroperoxide glutathione peroxidase; metabolic fatty liver |
| Journal Title: | Gastroenterology |
| Volume: | 167 |
| Issue: | 2 |
| ISSN: | 0016-5085 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-07-01 |
| Start Page: | 231 |
| End Page: | 249 |
| Language: | English |
| DOI: | 10.1053/j.gastro.2024.01.051 |
| PUBMED: | 38431204 |
| PROVIDER: | scopus |
| PMCID: | PMC11193643 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Xuejun Jiang -- Source: Scopus |
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