Emerging mechanisms and disease relevance of ferroptosis Journal Article


Authors: Stockwell, B. R.; Jiang, X.; Gu, W.
Article Title: Emerging mechanisms and disease relevance of ferroptosis
Abstract: Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating some cancers. Understanding the mechanisms governing cell death is critical for addressing its role in disease. Similarly, metabolism is essential for normal energy and biomolecule production, and goes awry in many diseases. Metabolism and cell death are tightly linked in the phenomenon of ferroptosis, a form of regulated cell death driven by peroxidation of phospholipids. Glutathione peroxidase 4 (GPX4) uses glutathione to protect cells from ferroptosis by eliminating phospholipid peroxides. Recent data have revealed glutathione/GPX4-independent axes for suppressing ferroptosis, and insight into the regulation of iron and mitochondria in ferroptosis. Ferroptosis has recently been implicated in multiple diseases, and functions as a tumor suppression mechanism. Ferroptosis induction is a promising approach in treating several conditions, including neoplastic diseases. Here, we summarize these recent advances. © 2020 Elsevier Ltd
Keywords: unclassified drug; review; nonhuman; metabolism; cell death; disease association; kidney failure; protein p53; cancer inhibition; iron; cell protection; lipid peroxidation; mitochondrion; ischemic heart disease; glutathione; liver injury; cerebrovascular accident; phospholipid; transcription factor nrf2; imidazole; ferroptosis; kelch like ech associated protein 1; human; priority journal; lipid peroxide; ubiquinone, cancer; imidazole ketone erastin; phospholipid hydroperoxide glutathione peroxidase
Journal Title: Trends in Cell Biology
Volume: 30
Issue: 6
ISSN: 0962-8924
Publisher: Elsevier Inc.  
Date Published: 2020-06-01
Start Page: 478
End Page: 490
Language: English
DOI: 10.1016/j.tcb.2020.02.009
PUBMED: 32413317
PROVIDER: scopus
PMCID: PMC7230071
DOI/URL:
Notes: Review -- Export Date: 1 June 2020 -- Source: Scopus
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  1. Xuejun Jiang
    92 Jiang