Metabolic programming of organ-specific natural killer cell responses Review
| Authors: | Delconte, R. B.; Sun, J. C. |
| Review Title: | Metabolic programming of organ-specific natural killer cell responses |
| Abstract: | Cells of the mammalian innate immune system have evolved to protect the host from various environmental or internal insults and injuries which perturb the homeostatic state of the organism. Among the lymphocytes of the innate immune system are natural killer (NK) cells, which circulate and survey host tissues for signs of stress, including infection or transformation. NK cells rapidly eliminate damaged cells in the blood or within tissues through secretion of cytolytic machinery and production of proinflammatory cytokines. To perform these effector functions while traversing between the blood and tissues, patrolling NK cells require sufficient fuel to meet their energetic demands. Here, we highlight the ability of NK cells to metabolically adapt across tissues, during times of nutrient deprivation and within tumor microenvironments. Whether at steady state, or during viral infection and cancer, NK cells readily shift their nutrient uptake and usage in order to maintain metabolism, survival, and function. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Keywords: | survival rate; review; nonhuman; systemic therapy; neoplasm; neoplasms; animal; metabolism; animals; cell function; protein bcl 2; steady state; bim protein; cytokine; immunology; cytokines; immune response; regulatory mechanism; organ specificity; natural killer cell; killer cells, natural; antibody specificity; effector cell; autoimmunity; innate immunity; immunity, innate; virus infection; immunity; nutrient; homeostasis; energy metabolism; food deprivation; metabolic regulation; circulation; tissue specificity; tumor microenvironment; nk cells; innate lymphoid cell; metabolic reprogramming; nutrient uptake; cancer; humans; human; malignant neoplasm; immunometabolism; receptor type tyrosine protein phosphatase c |
| Journal Title: | Immunological Reviews |
| Volume: | 323 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-05-01 |
| Start Page: | 8 |
| End Page: | 18 |
| Language: | English |
| DOI: | 10.1111/imr.13333 |
| PUBMED: | 38628147 |
| PROVIDER: | scopus |
| PMCID: | PMC11102308 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding authors are Rebecca B. Delconte and Joseph C. Sun -- Source: Scopus |
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