Coating a self-assembly nanoconstruct with a neutrophil cell membrane enables high specificity for triple negative breast cancer treatment Journal Article
| Authors: | Chowdhury, P.; Nagesh, P. K. B.; Hollingsworth, T. J.; Jaggi, M.; Chauhan, S. C.; Yallapu, M. M. |
| Article Title: | Coating a self-assembly nanoconstruct with a neutrophil cell membrane enables high specificity for triple negative breast cancer treatment |
| Abstract: | Breast cancer is one of the most commonly diagnosed cancers in American women. Triple negative breast cancer is among the most advanced and aggressive forms of breast cancer. Treatment options are limited for such cancers, making chemotherapy a convenient and effective treatment. Although these therapies can reduce morbidity and mortality, it is often followed by systemic side effects or relapse. Nanoparticles (NPs) have been considered for drug delivery approaches due to their ability to target various disease sites. Herein, we aim to develop a biomimetic NP construct (cell membrane-cloaked NPs) that exhibits specific affinity with triple negative breast cancer cells. In this regard, we designed biomimetic supramolecular nanoconstructs composed of a poly(vinyl pyrrolidone)-tannic acid (PVP-TA NPs/PVT NPs) core and biofunctionalized with neutrophil cell membranes (PVT-NEU NPs). In this study, we have synthesized a PVT-NEU NP construct, characterized it, and evaluated it for improved targeting and therapeutic benefits in in vitro and in vivo models. Analysis of PVT-NEU NPs confirms the presence of the core of PVP-TA NPs coated with activated human neutrophil membranes. The study results confirmed that PVT-NEU NPs demonstrated an enhanced interaction and targeting with the tumor cells, thus improving the therapeutic activity of a model therapeutic agent (paclitaxel). Altogether, this study suggests the potential of biomimetic NPs as a promising therapeutic option for targeted drug delivery for advanced-stage breast cancer and other similar diseased conditions. © 2022 American Chemical Society. |
| Keywords: | side effect; chemotherapy; cytology; breast cancer; medical nanotechnology; nanoparticles; nanomedicine; biomimetics; diseases; cancer cells; cells; triple negative breast cancer; self assembly; membranes; breast cancer cells; targeted drug delivery; controlled drug delivery; triple-negative breast cancers; breast cancer treatment; tannic acid; high specificity; biomimetic nanoparticles; membrane-cloaked nanoparticles; membrane-cloaked nanoparticle; polyvinylpyrrolidones |
| Journal Title: | ACS Applied Bio Materials |
| Volume: | 5 |
| Issue: | 9 |
| ISSN: | 2576-6422 |
| Publisher: | American Chemical Society |
| Date Published: | 2022-09-19 |
| Start Page: | 4554 |
| End Page: | 4566 |
| Language: | English |
| DOI: | 10.1021/acsabm.2c00614 |
| PROVIDER: | scopus |
| PUBMED: | 35976626 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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