In situ nanoparticle self-assembly for combination delivery of therapeutics to non-small cell lung cancer Journal Article
| Authors: | Hatami, E.; Nagesh, P. K. B.; Chauhan, N.; Jaggi, M.; Chauhan, S. C.; Yallapu, M. M. |
| Article Title: | In situ nanoparticle self-assembly for combination delivery of therapeutics to non-small cell lung cancer |
| Abstract: | Chemotherapy often experiences several challenges including severe systemic toxicity and adverse effects. The combination chemotherapy arose as an effective clinical practice aimed at reducing doses of drugs to achieve synergistic actions with low toxicity. Our recent efforts demonstrated a synergistic therapeutic benefit of gambogic acid (GA) and gemcitabine (Gem) against lung cancer. However, simultaneous delivery of these two drugs at the tumor site is highly challenging. Therefore, the development of an injectable formulation that can effectively deliver both hydrophobic (GA) and hydrophilic (Gem) drugs in one formulation is a clinically unmet need. Herein, this study reports an in situ human serum albumin (HSA)- and tannic acid (TA)-mediated complexed GA and Gem nanoparticles (G-G@HTA NPs). G-G@HTA NP formation was confirmed by the particle size, Fourier transform infrared spectroscopy, and 1H NMR spectroscopy. The superior therapeutic activity of G-G@HTA NPs was demonstrated by multiple in vitro functional assays. Additionally, G-G@HTA NPs revealed an obvious and precise targeting of tumors in vivo. The promoted and more synergistic anti-tumor efficacy of G-G@HTA NPs was attained than that of combined treatments and single drug treatments. These events have resulted in no apparent systemic and organ toxicities. Together, this study suggests that in situ HSA-TA-based combinatorial treatment strategy is a suitable approach for application in lung cancer treatment. © 2022 American Chemical Society. All rights reserved. |
| Keywords: | gemcitabine; chemotherapy; lung cancer; gambogic acid; drug resistance; tumors; nuclear magnetic resonance spectroscopy; medical nanotechnology; nanoparticles; nanomedicine; toxicity; biological organs; diseases; particle size; non small cell lung cancer; drug-resistance; adjuvant; self assembly; targeted drug delivery; cancer treatment; drug dosage; controlled drug delivery; fourier transform infrared spectroscopy; chemosensitizer; human serum albumins; nanoparticles self assemblies; tannic acid |
| Journal Title: | ACS Applied Bio Materials |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 2576-6422 |
| Publisher: | American Chemical Society |
| Date Published: | 2022-03-21 |
| Start Page: | 1104 |
| End Page: | 1119 |
| Language: | English |
| DOI: | 10.1021/acsabm.1c01158 |
| PUBMED: | 35179871 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 25 April 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work