A theranostic cellulose nanocrystal-based drug delivery system with enhanced retention in pulmonary metastasis of melanoma Journal Article
| Authors: | Imlimthan, S.; Khng, Y. C.; Keinänen, O.; Zhang, W.; Airaksinen, A. J.; Kostiainen, M. A.; Zeglis, B. M.; Santos, H. A.; Sarparanta, M. |
| Article Title: | A theranostic cellulose nanocrystal-based drug delivery system with enhanced retention in pulmonary metastasis of melanoma |
| Abstract: | Metastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA-approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium-177 (177Lu) enables simultaneous tracking of tracer accumulation with single-photon emission computed tomography and radiotherapy. Therefore, the codelivery of 177Lu alongside chemotherapeutic agents using nanoparticles (NPs) might improve the therapeutic outcome in metastatic melanoma. Cellulose nanocrystals (CNC NPs) can particularly deliver payloads to lung capillaries in vivo. Herein, 177Lu-labeled CNC NPs loaded with vemurafenib ([177Lu]Lu-CNC-V NPs) is developed and the therapeutic effect in BRAF V600E mutation-harboring YUMM1.G1 murine model of lung metastatic melanoma is investigated. The [177Lu]Lu-CNC-V NPs demonstrate favorable radiolabel stability, drug release profile, cellular uptake, and cell growth inhibition in vitro. In vivo biodistribution reveals significant retention of the [177Lu]Lu-CNC-V NPs in the lung, liver, and spleen. Ultimately, the median survival time of animals is doubly increased after treatment with [177Lu]Lu-CNC-V NPs compared to control groups. The enhanced therapeutic efficacy of [177Lu]Lu-CNC-V NPs in the lung metastatic melanoma animal model provides convincing evidence for the potential of clinical translation for theranostic CNC NP-based drug delivery systems after intravenous administration. © 2021 The Authors. Small published by Wiley-VCH GmbH |
| Keywords: | survival; cell proliferation; animals; oncology; processing; intravenous administration; biological organs; dermatology; drug delivery system; therapeutic efficacy; theranostics; metastatic melanoma; retention; single photon emission computed tomography; targeted drug delivery; clinical translation; chemotherapeutic agents; pulmonary metastasis; delivery; stability; vemurafenib; cellulose; lutetium-177; controlled drug delivery; particle beams; lutetium compounds; therapeutic outcomes; cellulose nanocrystal; theranostic nanosystem; cellulose derivatives; cellulose nanocrystals |
| Journal Title: | Small |
| Volume: | 17 |
| Issue: | 18 |
| ISSN: | 1613-6810 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2021-05-06 |
| Start Page: | 2007705 |
| Language: | English |
| DOI: | 10.1002/smll.202007705 |
| PUBMED: | 33738957 |
| PROVIDER: | scopus |
| PMCID: | PMC8175021 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2021 -- Source: Scopus |
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