Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care Review
| Authors: | Smalley, I.; Boire, A.; Brastianos, P.; Kluger, H. M.; Hernando-Monge, E.; Forsyth, P. A.; Ahmed, K. A.; Smalley, K. S. M.; Ferguson, S.; Davies, M. A.; Glitza Oliva, I. C. |
| Review Title: | Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care |
| Abstract: | Leptomeningeal disease (LMD) remains a major challenge in the clinical management of metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD continue to be excluded from almost all clinical trials. However, recent trials have demonstrated the feasibility of conducting prospective clinical trials in these patients. Further, new insights into the pathophysiology of LMD are identifying rational new therapeutic strategies. Here we present recent advances in the understanding of, and treatment options for, LMD from metastatic melanoma. We also annotate key areas of future focus to accelerate progress for this challenging but emerging field. © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| Keywords: | prospective study; prospective studies; melanoma; radiosurgery; central nervous system metastasis; leptomeningeal disease; humans; human |
| Journal Title: | Pigment Cell & Melanoma Research |
| Volume: | 37 |
| Issue: | 1 |
| ISSN: | 1755-1471 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-01-01 |
| Start Page: | 51 |
| End Page: | 67 |
| Language: | English |
| DOI: | 10.1111/pcmr.13116 |
| PUBMED: | 37622466 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
