Melanoma central nervous system metastases: Current approaches, challenges, and opportunities Journal Article
| Authors: | Cohen, J. V.; Tawbi, H.; Margolin, K. A.; Amravadi, R.; Bosenberg, M.; Brastianos, P. K.; Chiang, V. L.; de Groot, J.; Glitza, I. C.; Herlyn, M.; Holmen, S. L.; Jilaveanu, L. B.; Lassman, A.; Moschos, S.; Postow, M. A.; Thomas, R.; Tsiouris, J. A.; Wen, P.; White, R. M.; Turnham, T.; Davies, M. A.; Kluger, H. M. |
| Article Title: | Melanoma central nervous system metastases: Current approaches, challenges, and opportunities |
| Abstract: | Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| Keywords: | brain metastasis; clinical trials; tumor microenvironment; leptomeningeal disease; experimental models |
| Journal Title: | Pigment Cell & Melanoma Research |
| Volume: | 29 |
| Issue: | 6 |
| ISSN: | 1755-1471 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2016-11-01 |
| Start Page: | 627 |
| End Page: | 642 |
| Language: | English |
| DOI: | 10.1111/pcmr.12538 |
| PROVIDER: | scopus |
| PUBMED: | 27615400 |
| PMCID: | PMC5398760 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 6 December 2016 -- Source: Scopus |
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