Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions Review
| Authors: | Glitza, I. C.; Smalley, K. S. M.; Brastianos, P. K.; Davies, M. A.; McCutcheon, I.; Liu, J. K. C.; Ahmed, K. A.; Arrington, J. A.; Evernden, B. R.; Smalley, I.; Eroglu, Z.; Khushalani, N.; Margolin, K.; Kluger, H.; Atkins, M. B.; Tawbi, H.; Boire, A.; Forsyth, P. |
| Review Title: | Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions |
| Abstract: | In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| Keywords: | cancer survival; cancer surgery; clinical feature; review; nonhuman; systemic therapy; cancer patient; cancer radiotherapy; brain radiation; neuroimaging; neurosurgery; antineoplastic agent; cancer diagnosis; cancer immunotherapy; melanoma; tumor biopsy; diagnostic imaging; clinical research; cancer epidemiology; cancer tissue; molecular biology; catheter infection; brain hemorrhage; carcinomatous meningitis; basic research; leukoencephalopathy; cooperation; scientist; meningeal biopsy; translational research; circulating tumor cell; hydrocephalus; cerebrospinal fluid cytology; molecular pathology; clinical trial (topic); molecularly targeted therapy; neoplastic meningitis; leptomeningeal disease; clinician; cancer prognosis; leptomeningeal carcinomatosis; preclinical study; human; circulating tumor dna; intrathecal therapy; multidisciplinary team; biobank |
| Journal Title: | Pigment Cell & Melanoma Research |
| Volume: | 33 |
| Issue: | 4 |
| ISSN: | 1755-1471 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-07-01 |
| Start Page: | 527 |
| End Page: | 541 |
| Language: | English |
| DOI: | 10.1111/pcmr.12861 |
| PUBMED: | 31916400 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2020 -- Source: Scopus |
