Percutaneous image-guided ablation for hepatic metastases Review
| Authors: | Sotirchos, V. S.; Petre, E. N.; Sofocleous, C. T. |
| Review Title: | Percutaneous image-guided ablation for hepatic metastases |
| Abstract: | The presence of hepatic metastases indicates advanced disease and is associated with significant morbidity and mortality, especially when the hepatic disease is not amenable to locoregional treatments. The primary tumour of origin, the distribution and extent of metastatic disease, the underlying liver reserve, the patient performance status and the presence of comorbidities are factors that determine whether a patient will benefit from hepatectomy or local curative-intent treatments. For patients with metastatic colorectal cancer, the most common primary cancer that spreads to the liver, several studies have demonstrated a survival benefit for patients who can be treated with hepatectomy and/or percutaneous ablation, compared to those treated with chemotherapy alone. Despite advances in surgical techniques increasing the percentage of patients eligible for surgery, most patients have unresectable disease or are poor surgical candidates. Percutaneous ablation can be used to provide local disease control and prolong survival for both surgical and non-surgical candidates. This is typically offered to patients with small hepatic metastases that can be ablated with optimal (≥10 mm) or at least adequate minimum ablation margins (≥5 mm), as high local tumour control rates can be achieved for these patients which are comparable to surgical resection. This review summarizes available evidence and outcomes following percutaneous ablation of the most frequently encountered types of hepatic metastases in the clinical practice of interventional oncology. Patient selection, technical considerations, follow-up protocols and oncologic outcomes are presented and discussed. © 2023 Royal Australian and New Zealand College of Radiologists. |
| Keywords: | treatment outcome; overall survival; review; fluorouracil; patient selection; liver neoplasms; nuclear magnetic resonance imaging; follow up; clinical practice; colorectal cancer; progression free survival; computer assisted tomography; breast cancer; evidence based practice; patient monitoring; practice guideline; pathology; diagnostic imaging; colorectal neoplasms; liver metastasis; colorectal tumor; folinic acid; liver tumor; hepatectomy; tumor growth; oxaliplatin; radiofrequency ablation; ablation therapy; catheter ablation; liver metastases; microwave ablation; procedures; magnetic resonance cholangiopancreatography; humans; human; positron emission tomography-computed tomography; minimal ablation margin; irreversible electroporation treatment; percutaneous image guided ablation therapy |
| Journal Title: | Journal of Medical Imaging and Radiation Oncology |
| Volume: | 67 |
| Issue: | 8 |
| ISSN: | 1754-9477 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-12-01 |
| Start Page: | 832 |
| End Page: | 841 |
| Language: | English |
| DOI: | 10.1111/1754-9485.13594 |
| PUBMED: | 37944085 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK corresponding author is Constantinos Sofocleous -- Source: Scopus |
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53Sotirchos
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