Advances in diffuse glial tumors diagnosis Review
| Authors: | de Souza Godoy, L. F.; Paes, V. R.; Ayres, A. S.; Bandeira, G. A.; Moreno, R. A.; Hirata, F. D. C. C.; Silva, F. A. B.; Nascimento, F.; Neto, G. D. C. C.; Gentil, A. F.; Lucato, L. T.; Junior, E. A.; Young, R. J.; Malheiros, S. M. F. |
| Review Title: | Advances in diffuse glial tumors diagnosis |
| Abstract: | In recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms. This progress culminated in the fifth edition of the WHO classification of central nervous system (CNS) tumors in 2021. This comprehensive review article aims to elucidate these advances within a multidisciplinary framework, contextualized within the backdrop of the new classification. This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. It briefly reviews the usefulness of tractography and functional neuroimaging in surgical planning. Additionally, the article addresses the value of other functional imaging techniques such as perfusion MRI, spectroscopy, and nuclear medicine in distinguishing tumor progression from treatment-related changes. Furthermore, it discusses the advantages of evolving diagnostic techniques in classifying these tumors, as well as their limitations in terms of availability and utilization. Moreover, the expanding domains of data processing, artificial intelligence, radiomics, © 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution. |
| Keywords: | immunohistochemistry; mitogen activated protein kinase; adult; child; preschool child; aged; middle aged; young adult; unclassified drug; gene mutation; sequence analysis; genetics; review; cancer growth; neuroimaging; nuclear magnetic resonance imaging; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; cancer diagnosis; polymerase chain reaction; phenotype; dna repair; platelet derived growth factor alpha receptor; quality of life; tumor volume; epidermal growth factor receptor; atrophy; pathology; diagnostic imaging; necrosis; dna methylation; central nervous system tumor; central nervous system neoplasms; carcinogenesis; chromosome aberration; fluorescence in situ hybridization; artificial intelligence; glioblastoma; gene fusion; brain metastasis; telomerase reverse transcriptase; oligodendroglioma; nuclear medicine; cyclin dependent kinase inhibitor 2a; functional magnetic resonance imaging; dna methyltransferase; genetic screening; astrocytoma; spectroscopy; perfusion weighted imaging; isocitrate dehydrogenase; diffusion tensor imaging; peptides and proteins; fibroblast growth factor receptor; tractography; machine learning; interdisciplinary research; high throughput sequencing; data processing; functional neuroimaging; humans; human; male; female; radiomics; positron emission tomography-computed tomography; neurotrophic tyrosine receptor kinase; fluid-attenuated inversion recovery imaging; ► glioma ► neuroimaging ► biomarkers ► genetic profile ► pathology ► precision medicine ► machine learning; anaplastic lymphoma receptor tyrosine kinase; ezh inhibitory protein; met proto-oncogene receptor tyrosine kinase; mybl1 gene; plnty gene |
| Journal Title: | Arquivos de Neuro-Psiquiatria |
| Volume: | 81 |
| Issue: | 12 |
| ISSN: | 0004-282X |
| Publisher: | Association Arquivos Neuro-Psiquiatria |
| Date Published: | 2023-12-01 |
| Start Page: | 1134 |
| End Page: | 1145 |
| Language: | English |
| DOI: | 10.1055/s-0043-1777729 |
| PUBMED: | 38157879 |
| PROVIDER: | scopus |
| PMCID: | PMC10756793 |
| DOI/URL: | |
| Notes: | Review -- "Avanços no diagnóstico dos gliomas difusos" -- Source: Scopus |
