Neurocognitive changes in cancer survivors Journal Article
| Authors: | Correa, D. D.; Ahles, T. A. |
| Article Title: | Neurocognitive changes in cancer survivors |
| Abstract: | This article provides an overview of the most recent literature on the cognitive adverse effects of chemotherapy in patients with breast cancer. The prevalence of cognitive dysfunction in patients treated with chemotherapy was variable in studies using a crosssectional design. More recent prospective studies detected cognitive difficulties in subgroups of patients, mostly at short-term follow-ups, but other studies found no evidence of impairment. Studies using neuroimaging techniques and animal models have begun to examine structural and functional correlates of cognitive changes associated with chemotherapy. A review of the literature suggests that considerable progress has been made in the investigation of chemotherapy-related cognitive dysfunction in recent years, and highlights the importance of a multidisciplinary approach to further elucidate the mechanisms that may underlie treatment-related toxicity. Copyright © 2008 by Lippincott Williams & Wilkins. |
| Keywords: | cancer chemotherapy; controlled study; cancer surgery; cisplatin; doxorubicin; fluorouracil; nonhuman; antineoplastic agents; chemotherapy; cytarabine; methotrexate; neuroimaging; outcome assessment; follow up; prospective study; prospective studies; mouse; animals; breast cancer; prevalence; animal model; cyclophosphamide; diagnostic imaging; breast neoplasms; carmustine; ifosfamide; thiotepa; cancer survivor; survivors; rat; lymphoma; tamoxifen; cognition; medical literature; cognitive defect; cross-sectional study; cross-sectional studies; memory disorder; cognition disorders; intraductal carcinoma; brain damage; cognitive functions |
| Journal Title: | The Cancer Journal |
| Volume: | 14 |
| Issue: | 6 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-11-01 |
| Start Page: | 396 |
| End Page: | 400 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e31818d8769 |
| PUBMED: | 19060604 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 16" - "Export Date: 17 November 2011" - "CODEN: CAJOC" - "Source: Scopus" |
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