Human prostate MRI at ultrahigh-performance gradient: A feasibility study Journal Article
| Authors: | Zhu, A.; Tarasek, M.; Hua, Y.; Fiveland, E.; Maier, S. E.; Mazaheri, Y.; Fung, M.; Westin, C. F.; Yeo, D. T. B.; Szczepankiewicz, F.; Tempany, C.; Akin, O.; Foo, T. K. F. |
| Article Title: | Human prostate MRI at ultrahigh-performance gradient: A feasibility study |
| Abstract: | Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system. Methods: In this local institutional review board–approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 mT/m and slew rate of 500 T/m/s. PI-RADS V2.1–compliant axial T2-weighted anatomical imaging and single-shot echo planar DWI at standard gradient of 70 mT/m and 150 T/m/s were obtained, followed by DWI at maximum performance (i.e., 200 mT/m and 500 T/m/s). In comparison to state-of-the-art clinical whole-body MRI systems, the high slew rate improved echo spacing from 1020 to 596 μs and, together with a high gradient amplitude for diffusion encoding, TE was reduced from 55 to 36 ms. Results: In all 4 subjects (waist circumference = 81–91 cm, age = 45–65 years), no peripheral nerve stimulation sensation was reported during DWI. Reduced image distortion in the posterior peripheral zone prostate gland and higher signal intensity, such as in the surrounding muscle of high-gradient DWI, were noted. Conclusion: Human prostate MRI at simultaneously high gradient amplitude of 200 mT/m and slew rate of 500 T/m/s is feasible, demonstrating that improved gradient performance can address image distortion and T2 decay–induced SNR issues for in vivo prostate imaging. © 2023 International Society for Magnetic Resonance in Medicine. |
| Keywords: | adult; aged; middle aged; neuroimaging; nuclear magnetic resonance imaging; magnetic resonance imaging; reproducibility; reproducibility of results; in vivo study; diagnostic imaging; prostatic neoplasms; prostate; feasibility study; image enhancement; feasibility studies; prostate tumor; urology; waist circumference; safety; diffusion weighted imaging; diffusion magnetic resonance imaging; normal human; nerve stimulation; human experiment; echo planar imaging; radiological parameters; procedures; echo-planar imaging; human prostate; whole body mri; humans; human; male; article; diffusion mri; electromagnetism; prostate imaging reporting and data system; t2 weighted imaging; echo time; image distortion; ultrahigh-performance gradient; high gradient; image distortions; mri systems; slew rate; ultra high performance |
| Journal Title: | Magnetic Resonance in Medicine |
| Volume: | 91 |
| Issue: | 2 |
| ISSN: | 0740-3194 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-02-01 |
| Start Page: | 640 |
| End Page: | 648 |
| Language: | English |
| DOI: | 10.1002/mrm.29874 |
| PUBMED: | 37753628 |
| PROVIDER: | scopus |
| PMCID: | PMC10841413 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in PubMed and PDF -- Source: Scopus |
