The spectrum of headache in leptomeningeal metastases: A comprehensive review with clinical management guidelines Review
| Authors: | Wilcox, J. A.; Estrera, R.; Boire, A. |
| Review Title: | The spectrum of headache in leptomeningeal metastases: A comprehensive review with clinical management guidelines |
| Abstract: | Purpose of Review: Headaches are a common, oftentimes debilitating symptom in patients with leptomeningeal metastases. Recent Findings: The third edition of the International Classification of Headache Disorders provides a useful diagnostic framework for headaches secondary to leptomeningeal metastases based on the temporal relationship of headache with disease onset, change in headache severity in correlation with leptomeningeal disease burden, and accompanying neurologic signs such as cranial nerve palsies and encephalopathy. However, headaches in patients with leptomeningeal metastases can be further defined by a wide range of varying cancer- and treatment-related pathophysiologies, each requiring a tailored approach. Summary: A thorough review of the literature and expert opinion on five observed headache sub-classifications in patients with leptomeningeal metastases is provided, with attention to necessary diagnostic testing, recommended first-line treatments, and prevention strategies. © 2023, The Author(s). |
| Keywords: | headache; leptomeningeal metastases; intracranial pressure; intrathecal chemotherapy; humans; human; headache disorders; headache and facial pain; whole-brain radiation therapy |
| Journal Title: | Current Pain and Headache Reports |
| Volume: | 27 |
| Issue: | 11 |
| ISSN: | 1531-3433 |
| Publisher: | Springer |
| Date Published: | 2023-11-01 |
| Start Page: | 695 |
| End Page: | 706 |
| Language: | English |
| DOI: | 10.1007/s11916-023-01180-9 |
| PUBMED: | 37874457 |
| PROVIDER: | scopus |
| PMCID: | PMC10713777 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Adrienne Boire -- Source: Scopus |
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