Primary leptomeningeal primitive neuroectodermal tumor Journal Article
| Authors: | Begemann, M.; Lyden, D.; Rosenblum, M. K.; Lis, E.; Wolden, S.; Antunes, N. L.; Dunkel, I. J. |
| Article Title: | Primary leptomeningeal primitive neuroectodermal tumor |
| Abstract: | Leptomeningeal metastases are a common complication of medulloblastomas and other primitive neuroectodermal tumors (PNETs). Much rarer are PNETs apparently arising in the leptomeninges. An 8-year-old boy presented with headache and vomiting, due to neoplastic meningitis from primary neuroectodermal tumor without an identifying mass. After craniospinal irradiation and chemotherapy (carboplatin, vincristine, cyclophosphamide and lomustine) the boy was in remission for 14 months, then suffered several relapses despite various chemotherapy regimens. After the initial presentation of 3.5 years the boy began to suffer from prolonged refractory non-convulsive status epilepticus and later expired from progression of primary leptomeningeal PNET. |
| Keywords: | child; school child; case report; cancer combination chemotherapy; cancer growth; multimodality cancer therapy; radiation dose; combined modality therapy; temozolomide; nuclear magnetic resonance imaging; magnetic resonance imaging; antineoplastic agent; carboplatin; etoposide; vomiting; antineoplastic combined chemotherapy protocols; radiotherapy dosage; lorazepam; cyclophosphamide; dexamethasone; vincristine; stem cell transplantation; tumor regression; pathology; lomustine; thiotepa; skull irradiation; cranial irradiation; irinotecan; papilledema; phenobarbital; lumbar puncture; meningeal neoplasms; immunocytochemistry; tumor recurrence; remission; remission induction; headache; physical examination; meningioma; diplopia; fatal outcome; neuroectoderm tumor; carcinomatous meningitis; visual impairment; phenytoin; valproic acid; neuroectodermal tumors, primitive; cerebrospinal fluid cytology; fatality; epileptic state; leptomeninx; neoplastic meningitis; disease resistance; leptomeninges; pnet; humans; human; male; article; non-convulsive status epilepticus; primary leptomeningeal pnet |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 63 |
| Issue: | 3 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2003-07-01 |
| Start Page: | 299 |
| End Page: | 303 |
| Language: | English |
| DOI: | 10.1023/a:1024324700411 |
| PUBMED: | 12892237 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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