Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors Review
| Authors: | Diaz, M.; Chudsky, S.; Pentsova, E.; Miller, A. M. |
| Review Title: | Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors |
| Abstract: | For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this disease. The ctDNA technology has been studied in a variety of primary and metastatic brain and spinal cord tumors, where it can be used for diagnosis and molecular classification, with some work suggesting that it may also be useful for longitudinal tracking of tumor evolution or as a marker of residual disease. This review summarizes recent publications on the use of these two tests in CSF, focusing on their established and potential clinical applications. © 2024 |
| Keywords: | gene mutation; solid tumor; flow cytometry; nuclear magnetic resonance imaging; brain tumor; glioma; gold standard; polymerase chain reaction; multiple myeloma; tumor marker; central nervous system tumor; cerebrospinal fluid; lumbar puncture; glioblastoma; medulloblastoma; brain metastasis; immunophenotyping; tumor growth; circulating tumor cells; epithelium tumor; brain tumors; circulating tumor cell; cerebrospinal fluid cytology; non small cell lung cancer; tumor biomarkers; disease burden; human; article; whole genome sequencing; circulating tumor dna; droplet digital polymerase chain reaction; whole exome sequencing; liquid biopsy; cell-free dna; circulating free dna; leptomeningeal melanoma |
| Journal Title: | Translational Oncology |
| Volume: | 41 |
| ISSN: | 1936-5233 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2024-01-01 |
| Start Page: | 101881 |
| Language: | English |
| DOI: | 10.1016/j.tranon.2024.101881 |
| PROVIDER: | scopus |
| PMCID: | PMC10825768 |
| PUBMED: | 38218027 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Alexandra M. Miller -- Source: Scopus |
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