Moving into the modern era of molecular classification for endometrial cancer Review

  


Authors: Dagher, C.; Liu, Y. L.; Mueller, J. J.; Weigelt, B.
Review Title: Moving into the modern era of molecular classification for endometrial cancer
Abstract: The molecular subtypes of endometrial carcinoma (EC) were first described by The Cancer Genome Atlas (TCGA) a decade ago. Using surrogate approaches, the molecular classification has been demonstrated to be prognostic across EC patients and to have predictive implications. Starting in 2020, the molecular classification has been incorporated into multiple guidelines as part of the risk assessment and most recently into the International Federation of Gynecology and Obstetrics (FIGO) staging. This review article discusses the implementation of the EC molecular classification into clinical practice, the therapeutic implications, and the molecular and clinical heterogeneity of the EC molecular subtypes. © 2023 Wiley Periodicals LLC.
Keywords: genetics; cancer staging; endometrial cancer; endometrial neoplasms; neoplasm staging; pathology; prediction; endometrium tumor; heterogeneity; molecular classification; humans; prognosis; human; female
Journal Title: Journal of Surgical Oncology
Volume: 129
Issue: 1
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2024-01-01
Start Page: 120
End Page: 125
Language: English
DOI: 10.1002/jso.27552
PUBMED: 38100711
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179900576&doi=10.1002%2fjso.27552&partnerID=40&md5=1cf3c61c95104dc49ec966ab36ae31c2
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Britta Weigelt -- Source: Scopus
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MSK Authors
  1. Britta Weigelt
    632 Weigelt
  2. Jennifer Jean Mueller
    186 Mueller
  3. Ying Liu
    105 Liu
  4. Christian Dagher
    26 Dagher
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