Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy Journal Article

  


Authors: Cadoo, K. A.; Traina, T. A.; King, T. A.
Article Title: Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy
Abstract: The identification of the intrinsic molecular subtypes of breast cancer has enhanced our understanding of tumor biology, informing therapeutic targets, and clinical trial design. This article reviews the intrinsic classification system and the clinically defined subtypes of breast cancer. We review the molecular drivers of each subtype and discuss implications for prognosis, clinical management, and future directions. © 2013 Elsevier Inc.
Keywords: signal transduction; cancer survival; protein expression; treatment outcome; unclassified drug; review; cisplatin; cancer combination chemotherapy; monotherapy; carboplatin; multiple cycle treatment; breast cancer; anemia; stomatitis; epidermal growth factor receptor; epidermal growth factor receptor 2; aromatase inhibitor; cetuximab; cancer resistance; exemestane; irinotecan; cancer hormone therapy; dyspnea; hyperglycemia; pneumonia; mammalian target of rapamycin; drug response; tamoxifen; androgen receptor; letrozole; bicalutamide; platinum complex; cancer classification; trastuzumab; anastrozole; breast metastasis; triple negative; everolimus; rapamycin; lapatinib; resistance; epidermal growth factor receptor kinase inhibitor; fulvestrant; endocrine therapy; protein pik3ca; triple negative breast cancer; trastuzumab emtansine; cancer prognosis; her2 gene; estrogen receptor positive breast cancer; pictilisib; intrinsic subtypes; her2 positive; buparlisib; claudin; phosphatidylinositol 4,5 bisphosphate 3 kinase; basal like breast cancer
Journal Title: Surgical Oncology Clinics of North America
Volume: 22
Issue: 4
ISSN: 1055-3207
Publisher: Elsevier Inc.  
Date Published: 2013-10-01
Start Page: 823
End Page: 840
Language: English
DOI: 10.1016/j.soc.2013.06.006
PROVIDER: scopus
PUBMED: 24012401
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84883552212&partnerID=40&md5=7e3f030429610dc703eb533074ee0acb
Notes: --- - "Export Date: 1 October 2013" - "CODEN: SOCAF" - "Source: Scopus"
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MSK Authors
  1. Tari King
    186 King
  2. Tiffany A Traina
    250 Traina
  3. Karen Anne Cadoo
    113 Cadoo
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