Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology Journal Article
| Authors: | Damrauer, J. S.; Hoadley, K. A.; Chism, D. D.; Fan, C.; Tiganelli, C. J.; Wobker, S. E.; Yeh, J. J.; Milowsky, M. I.; Iyer, G.; Parker, J. S.; Kim, W. Y. |
| Article Title: | Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology |
| Abstract: | We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of highgrade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed "luminal" and "basal-like," which have characteristics of different stages of urothelial differentiation, reflect the luminal and basal-like molecular subtypes of breast cancer, and have clinically meaningful differences in outcome. A gene set predictor, bladder cancer analysis of subtypes by gene expression (BASE47) was defined by prediction analysis of microarrays (PAM) and accurately classifies the subtypes. Our data demonstrate that there are at least two molecularly and clinically distinct subtypes of high-grade bladder cancer and validate the BASE47 as a subtype predictor. Future studies exploring the predictive value of the BASE47 subtypes for standard of care bladder cancer therapies, as well as novel subtype-specific therapies, will be of interest. |
| Keywords: | cancer survival; unclassified drug; overall survival; cancer grading; cell survival; breast cancer; cluster analysis; gene expression; cell motion; cell differentiation; bladder cancer; fibroblast growth factor receptor 3; bladder tumor; correlation analysis; cytokeratin 20; upregulation; cancer classification; cytokeratin 14; cytokeratin 5; cytokeratin 6; cyclin d1; molecular weight; disease specific survival; cyclin e; breast development; epithelial mesenchymal transition; transcription factor e2f3; cyclin e1; basal like breast cancer; human; priority journal; article; claudin 3; claudin 4; claudin 7; cytokeratin 6b; uroplakin 1b; uroplakin 2; uroplakin 3; uroplakin 3a |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 111 |
| Issue: | 8 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2014-02-25 |
| Start Page: | 3110 |
| End Page: | 3115 |
| Language: | English |
| DOI: | 10.1073/pnas.1318376111 |
| PROVIDER: | scopus |
| PMCID: | PMC3939870 |
| PUBMED: | 24520177 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2014 -- CODEN: PNASA -- Source: Scopus |
