Small cell lung cancer profiling: An updated synthesis of subtypes, vulnerabilities, and plasticity Review

  


Authors: Redin, E.; Quintanal-Villalonga, Á; Rudin, C. M.
Review Title: Small cell lung cancer profiling: An updated synthesis of subtypes, vulnerabilities, and plasticity
Abstract: Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic capacity. SCLC has been classified into molecular subtypes based on differential expression of lineage-defining transcription factors. Recent studies have proposed new subtypes that are based on both tumor-intrinsic and -extrinsic factors. SCLC demonstrates substantial intratumoral subtype heterogeneity characterized by highly plastic transcriptional states, indicating that the initially dominant subtype can shift during disease progression and in association with resistance to therapy. Strategies to promote or constrain plasticity and cell fate transitions have nominated novel targets that could prompt the development of more durably effective therapies for patients with SCLC. In this review, we describe the latest advances in SCLC subtype classification and their biological and clinical implications. © 2024
Keywords: genetics; review; metabolism; metastasis; gene expression; gene expression profiling; lung neoplasms; transcription factor; cell fate; pathology; tumor marker; lung tumor; gene expression regulation; gene expression regulation, neoplastic; drug combination; lung; drug therapy; therapy; pharmacology; small cell lung cancer; small cell lung carcinoma; plasticity; sclc; molecular subtypes; cell plasticity; vulnerability; humans; human; male; biomarkers, tumor; therapeutic vulnerabilities
Journal Title: Trends in Cancer
Volume: 10
Issue: 10
ISSN: 2405-8025
Publisher: Cell Press  
Date Published: 2024-10-01
Start Page: 935
End Page: 946
Language: English
DOI: 10.1016/j.trecan.2024.07.008
PUBMED: 39164163
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201618401&doi=10.1016%2fj.trecan.2024.07.008&partnerID=40&md5=6027cf15dbed7a2a1e39825e67785e34
Notes: Review -- MSK corresponding authors are Esther Redin and Charles Rudin -- Source: Scopus
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MSK Authors
  1. Charles Rudin
    488 Rudin
  2. Alvaro Diego Quintanal Villalonga
    63 Quintanal Villalonga
  3. Ester Redin Resano
    10 Redin Resano
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