Cardinal features of immune memory in innate lymphocytes Review
| Authors: | Santosa, E. K.; Sun, J. C. |
| Review Title: | Cardinal features of immune memory in innate lymphocytes |
| Abstract: | The ability of vertebrates to ‘remember’ previous infections had once been attributed exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess memory properties akin to those of adaptive immune cells. In this Review, we draw parallels from T cell biology to explore the key features of immune memory in innate lymphocytes, including quantity, quality, and location. We discuss the signals that trigger clonal or clonal-like expansion in innate lymphocytes, and highlight recent studies that shed light on the complex cellular and molecular crosstalk between metabolism, epigenetics, and transcription responsible for differentiating innate lymphocyte responses towards a memory fate. Additionally, we explore emerging evidence that activated innate lymphocytes relocate and establish themselves in specific peripheral tissues during infection, which may facilitate an accelerated response program akin to those of tissue-resident memory T cells. © 2023, Springer Nature America, Inc. |
| Keywords: | human cell; review; t lymphocyte; animal; cytology; metabolism; animals; genetic transcription; resident; epigenetics; innate immunity; immunity, innate; cell clone; memory; adaptive immunity; lymphocyte; lymphocytes; clone cells; immunocompetent cell; immunologic memory; immunological memory; memory t lymphocyte; human |
| Journal Title: | Nature Immunology |
| Volume: | 24 |
| Issue: | 11 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2023-11-01 |
| Start Page: | 1803 |
| End Page: | 1812 |
| Language: | English |
| DOI: | 10.1038/s41590-023-01607-w |
| PUBMED: | 37828377 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Joseph C. Sun -- Source: Scopus |
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