The significance of International Federation of Gynecology and Obstetrics grading in microsatellite instability-high and POLE-mutant endometrioid endometrial carcinoma Journal Article

   

Authors:	Kertowidjojo, E.; Momeni-Boroujeni, A.; Rios-Doria, E.; Abu-Rustum, N.; Soslow, R. A.
Article Title:	The significance of International Federation of Gynecology and Obstetrics grading in microsatellite instability-high and POLE-mutant endometrioid endometrial carcinoma
Abstract:	With the advancement of diagnostic molecular technology and the molecular classification of endometrial endometrioid carcinoma (EEC), it remains to be seen whether conventional Interna-tional Federation of Gynecology and Obstetrics (FIGO) grading retains clinical significance in certain molecular subtypes of EECs. In this study, we explored the clinical significance of FIGO grading in microsatellite instability-high (MSI-H) and POLE-mutant EECs. A total of 162 cases of MSI-H EECs and 50 cases of POLE-mutant EECs were included in the analysis. Significant differences in tumor mu-tation burden (TMB), progression-free survival, and disease-specific survival were seen between the MSI-H and POLE-mutant cohorts. Within the MSI-H cohort, there were statistically significant dif-ferences in TMB and stage at presentation across FIGO grades, but not survival. Within the POLE -mutant cohort, there was significantly greater TMB with increasing FIGO grade, but there were no significant differences in stage or survival. In both the MSI-H and POLE-mutant cohorts, log-rank survival analysis showed no statistically significant difference in progression-free and disease -specific survival across FIGO grades. Similar findings were also seen when a binary grading sys-tem was utilized. Since FIGO grade was not associated with survival, we conclude that the intrinsic biology of these tumors, characterized by their molecular profile, may override the significance of FIGO grading.& COPY; 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.
Keywords:	survival; endometrioid carcinoma; reproducibility; classification; histology; stage; system; mlh1; cancers; pole; figo grade; microsatellite instability-high; msi-h; international federation of; gynecology and obstetrics grade
Journal Title:	Modern Pathology
Volume:	36
Issue:	9
ISSN:	0893-3952
Publisher:	Nature Research
Date Published:	2023-09-01
Start Page:	100234
Language:	English
ACCESSION:	WOS:001034118700001
DOI:	10.1016/j.modpat.2023.100234
PROVIDER:	wos
PUBMED:	37268062
PMCID:	PMC10528952
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/209135