The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: A multidisciplinary expert consensus Review

   


Authors: Kaidar-Person, O.; Pfob, A.; Gentilini, O. D.; Borisch, B.; Bosch, A.; Cardoso, M. J.; Curigliano, G.; De Boniface, J.; Denkert, C.; Hauser, N.; Heil, J.; Knauer, M.; Kühn, T.; Lee, H. B.; Loibl, S.; Mannhart, M.; Meattini, I.; Montagna, G.; Pinker, K.; Poulakaki, F.; Rubio, I. T.; Sager, P.; Steyerova, P.; Tausch, C.; Tramm, T.; Vrancken Peeters, M. J.; Wyld, L.; Yu, J. H.; Weber, W. P.; Poortmans, P.; Dubsky, P.
Review Title: The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: A multidisciplinary expert consensus
Abstract: Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to local therapy of the axilla. Five working packages were developed, following the patients’ journey and addressing specific clinical scenarios. Panellists voted on 72 statements, reaching consensus (agreement of 75% or more) in 52.8%, majority (51%–74% agreement) in 43.1%, and no decision in 4.2%. Based on the votes, targeted imaging and standardized pathology of lymph nodes should be a prerequisite to planning local and systemic therapy, axillary lymph node dissection can be replaced by sentinel lymph node biopsy ( ± targeted approaches) in a majority of scenarios; and positive patient outcomes should be driven by both low recurrence risks and low rates of lymphoedema. © 2023 The Author(s)
Keywords: consensus; breast cancer; axillary management; patient journey
Journal Title: eClinicalMedicine
Volume: 61
ISSN: 2589-5370
Publisher: Elsevier Inc.  
Date Published: 2023-07-01
Start Page: 102085
Language: English
DOI: 10.1016/j.eclinm.2023.102085
PROVIDER: scopus
PMCID: PMC10388578
PUBMED: 37528842
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85165682143&doi=10.1016%2fj.eclinm.2023.102085&partnerID=40&md5=f3f158f409ee754d7ce66e60ee036c55
Notes: Review -- Source: Scopus
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