The Society of Thoracic Surgeons/American Society for radiation oncology updated clinical practice guidelines on multimodality therapy for locally advanced cancer of the esophagus or gastroesophageal junction Guidelines


Authors: Worrell, S. G.; Goodman, K. A.; Altorki, N. K.; Ashman, J. B.; Crabtree, T. D.; Dorth, J.; Firestone, S.; Harpole, D. H.; Hofstetter, W. L.; Hong, T. S.; Kissoon, K.; Ku, G. Y.; Molena, D.; Tepper, J. E.; Watson, T. J.; Williams, T.; Willett, C.
Title: The Society of Thoracic Surgeons/American Society for radiation oncology updated clinical practice guidelines on multimodality therapy for locally advanced cancer of the esophagus or gastroesophageal junction
Abstract: Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorporated the input of surgeons, radiation oncologists, and medical oncologists. To address the need for multidisciplinary input in the management of esophageal cancer and to meet current best practices for clinical practice guidelines, the current guidelines were created as a collaboration between The Society of Thoracic Surgeons (STS), American Society for Radiation Oncology (ASTRO), and the American Society of Clinical Oncology (ASCO). Physician representatives chose 8 key clinical questions pertinent to the care of patients with locally advanced, resectable thoracic esophageal cancer (excluding cervical location). A comprehensive literature review was performed identifying 227 articles that met the inclusion criteria covering the use of induction chemotherapy, chemotherapy vs chemoradiotherapy before surgery, optimal radiation dose, the value of esophagectomy, timing of esophagectomy, the approach and extent of lymphadenectomy, the use of minimally invasive esophagectomy, and the value of adjuvant therapy after resection. The relevant data were reviewed and voted on by the panel with 80% of the authors, with 75% agreement on class and level of evidence. These data were then complied into the guidelines document. © 2023 American Society for Radiation Oncology, The Society of Thoracic Surgeons
Journal Title: Practical Radiation Oncology
Volume: 14
Issue: 1
ISSN: 1879-8519
Publisher: Elsevier Inc.  
Date Published: 2024-01-01
Start Page: 28
End Page: 46
Language: English
DOI: 10.1016/j.prro.2023.10.001
PROVIDER: scopus
PUBMED: 37921736
DOI/URL:
Notes: Article -- Source: Scopus
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  1. Geoffrey Yuyat Ku
    230 Ku
  2. Daniela   Molena
    271 Molena