Regional nodal management in the setting of up-front surgery Review

   


Authors: Braunstein, L. Z.; Morrow, M.
Review Title: Regional nodal management in the setting of up-front surgery
Abstract: Historically, axillary lymph node dissection was considered necessary for regional control of breast cancer. Moreover, nodal status was the major determinant of the need for chemotherapy. The increased use of systemic therapy coupled with expanding indications for nodal irradiation has led to interest in optimizing patient outcomes by leveraging the local control benefits of radiotherapy and systemic therapy to decrease the extent of surgery. A series of landmark surgical and radiotherapeutic trials has demonstrated low rates of disease recurrence with concomitant improvements in treatment-associated lymphedema and quality of life with the use of sentinel node biopsy and nodal irradiation as opposed to complete axillary dissection in the management of node positive breast cancer. This chapter will explore the evolution of regional nodal management, culminating in current approaches to tailored patient selection for axillary lymph node dissection, sentinel lymph node biopsy, and adjuvant regional nodal irradiation. © 2022 Elsevier Inc.
Keywords: lymph node metastasis; lymph node dissection; lymph nodes; lymphatic metastasis; lymph node excision; sentinel lymph node biopsy; quality of life; pathology; breast neoplasms; breast tumor; lymph node; axilla; humans; human; female
Journal Title: Seminars in Radiation Oncology
Volume: 32
Issue: 3
ISSN: 1053-4296
Publisher: Elsevier Inc.  
Date Published: 2022-07-01
Start Page: 221
End Page: 227
Language: English
DOI: 10.1016/j.semradonc.2022.01.004
PUBMED: 35688520
PROVIDER: scopus
PMCID: PMC9199584
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124549164&doi=10.1016%2fj.semradonc.2022.01.004&partnerID=40&md5=58747a78a9bd7a1cfb5e42b21f8a646d
Identifier: PMC9199584
Notes: Review -- Export Date: 1 July 2022 -- Source: Scopus
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MSK Authors
  1. Monica Morrow
    772 Morrow
  2. Lior Z Braunstein
    169 Braunstein
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