The need for lymph node dissection in nonmetastatic breast cancer Journal Article


Authors: Pesce, C.; Morrow, M.
Article Title: The need for lymph node dissection in nonmetastatic breast cancer
Abstract: Determining whether cancer has spread to locoregional lymph nodes is a critical step in the initial staging of breast cancer patients. Although axillary dissection reliably identifies nodal metastases and prevents the recurrence of cancer in the axilla, there is a significant incidence of long-term side effects, notably lymphedema, and the procedure is of no therapeutic benefit in women without axillary metastases.With the advent of sentinel lymph node biopsy, the axilla can be accurately staged in patients with T1-T3, clinically node-negative breast cancers while avoiding the morbidity of axillary lymph node dissection if the nodes do not contain cancer. Recent clinical trials suggest that for women with metastases to 1 or 2 sentinel nodes, the radiation and systemic therapy that are part of modern multimodality breast cancer treatment can replace axillary dissection when breast-conserving therapy is undertaken. For those with greater disease burden or those undergoingmastectomy, axillary dissection remains standard management. Copyright © 2013 by Annual Reviews.
Keywords: treatment outcome; cancer surgery; cancer recurrence; cancer radiotherapy; lymph node metastasis; lymph node dissection; sentinel lymph node; sentinel lymph node biopsy; breast cancer; mastectomy; morbidity; postoperative complication; lymphedema; axillary lymph node; disease severity; micrometastasis; hematoma; seroma; treatment contraindication; wound infection; breast surgery; axillary dissection; positive sentinel node; sentinel lymph node biopsy (slnb); axillary hematoma; nonmetastatic breast cancer
Journal Title: Annual Review of Medicine
Volume: 64
ISSN: 0066-4219
Publisher: Annual Reviews  
Date Published: 2013-01-01
Start Page: 119
End Page: 129
Language: English
DOI: 10.1146/annurev-med-052511-135500
PROVIDER: scopus
PUBMED: 23020881
DOI/URL:
Notes: --- - "Export Date: 1 March 2013" - "CODEN: ARMCA" - "Source: Scopus"
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MSK Authors
  1. Monica Morrow
    640 Morrow
  2. Catherine Elizabeth Pesce
    5 Pesce