Modeling clinical outcomes in radiotherapy: NTCP, TCP and the “TECs” Review
| Author: | Yorke, E. |
| Review Title: | Modeling clinical outcomes in radiotherapy: NTCP, TCP and the “TECs” |
| Abstract: | Radiation therapy is a double-edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely have a unified understanding of the dosimetric and clinical correlates of the desired outcomes. I am fortunate to have participated in some of these struggles, including analyzing and using in-house data and being involved in the AAPM and ASTRO “TEC” projects—QUANTEC (Quantitatie Analysis of Normal Tissue Effects in the Clinic), HyTEC (Hypofractionated Treatment Effects in the Clinic) and PENTEC (Pediatric Normal Tissue Effects in the Clinic). © 2023 American Association of Physicists in Medicine. |
| Keywords: | child; review; intensity modulated radiation therapy; treatment planning; cancer radiotherapy; clinical practice; neoplasm; neoplasms; radiotherapy dosage; radiotherapy; tumors; radiation dose fractionation; probability; outcome; radiometry; radiotherapy planning, computer-assisted; photon therapy; cancer control; stereotactic body radiation therapy; radiation dose distribution; outcomes; normal tissue; radiation pneumonia; hypofractionated; conformal radiotherapy; tumor control probability; normal tissue complication probabilities; ntcp; clinical outcome; dose volume histogram; treatment effects; tcp; hypofractionated radiotherapy; humans; human; normal tissue complication probability; transmission control protocol |
| Journal Title: | Medical Physics |
| Volume: | 50 |
| Issue: | Suppl. 1 |
| ISSN: | 0094-2405 |
| Publisher: | American Association of Physicists in Medicine |
| Date Published: | 2023-06-01 |
| Start Page: | 122 |
| End Page: | 124 |
| Language: | English |
| DOI: | 10.1002/mp.16274 |
| PUBMED: | 36751020 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Ellen Yorke -- Source: Scopus |
