Moving spatially resolved multiplexed protein profiling toward clinical oncology Review
| Authors: | Pourmaleki, M.; Socci, N. D.; Hollmann, T. J.; Mellinghoff, I. K. |
| Review Title: | Moving spatially resolved multiplexed protein profiling toward clinical oncology |
| Abstract: | The shift in cancer therapy from broadly cytotoxic agents toward "personalized" treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology. ©2023 The Authors; Published by the American Association for Cancer Research. |
| Keywords: | neoplasm; neoplasms; proteins; protein; pathology; oncology; medical oncology; humans; human |
| Journal Title: | Cancer Discovery |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2023-04-01 |
| Start Page: | 824 |
| End Page: | 828 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-22-1015 |
| PUBMED: | 37009699 |
| PROVIDER: | scopus |
| PMCID: | PMC10070169 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding author is MSK author Ingo K. Mellinghoff -- Source: Scopus |
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