The role of stroma in cancer metabolism Review
| Authors: | Kimmelman, A. C.; Sherman, M. H. |
| Review Title: | The role of stroma in cancer metabolism |
| Abstract: | The altered metabolism of tumor cells is a well-known hallmark of cancer and is driven by multiple factors such as mutations in oncogenes and tumor suppressor genes, the origin of the tissue where the tumor arises, and the microenvironment of the tumor. These metabolic changes support the growth of cancer cells by providing energy and the necessary building blocks to sustain proliferation. Targeting these metabolic alterations therapeutically is a potential strategy to treat cancer, but it is challenging due to the metabolic plasticity of tumors. Cancer cells have developed ways to scavenge nutrients through autophagy and macropinocytosis and can also form metabolic networks with stromal cells in the tumor microenvironment. Understanding the role of the tumor microenvironment in tumor metabolism is crucial for effective therapeutic targeting. This review will discuss tumor metabolism and the contribution of the stroma in supporting tumor growth through metabolic interactions. © 2024 Cold Spring Harbor Laboratory Press; all rights reserved;. |
| Keywords: | nonhuman; neoplasm; neoplasms; animal; metabolism; animals; cell viability; serine; mitogenesis; pathology; cancer therapy; carcinogenesis; wound healing; oncogene; cancer cell; lymph node; paracrine signaling; stroma; rna translation; tumor growth; autophagy; stroma cell; stromal cells; tumor vascularization; lipid metabolism; metabolic disorder; metabolic regulation; nucleic acid; futurology; mechanotransduction; catabolism; tumor microenvironment; molecularly targeted therapy; cancer associated fibroblast; tumor metabolism; branched chain amino acid; macropinocytosis; metabolic reprogramming; humans; human; article; cells by body anatomy; malignant neoplasm; autophagy (cellular); sequestosome 1; cancer signaling |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 14 |
| Issue: | 5 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2024-05-01 |
| Start Page: | a041540 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a041540 |
| PUBMED: | 37696660 |
| PROVIDER: | scopus |
| PMCID: | PMC10925555 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Mara Sherman -- Source: Scopus |
