Biomineralogical signatures of breast microcalcifications Journal Article
| Authors: | Kunitake, J. A. M. R.; Sudilovsky, D.; Johnson, L. M.; Loh, H. C.; Choi, S.; Morris, P. G.; Jochelson, M. S.; Iyengar, N. M.; Morrow, M.; Masic, A.; Fischbach, C.; Estroff, L. A. |
| Article Title: | Biomineralogical signatures of breast microcalcifications |
| Abstract: | Microcalcifications, primarily biogenic apatite, occur in cancerous and benign breast pathologies and are key mammographic indicators. Outside the clinic, numerous microcalcification compositional metrics (e.g., carbonate and metal content) are linked to malignancy, yet microcalcification formation is dependent on microenvironmental conditions, which are notoriously heterogeneous in breast cancer. We interrogate multiscale heterogeneity in 93 calcifications from 21 breast cancer patients using an omics-inspired approach: For each microcalcification, we define a "biomineralogical signature"combining metrics derived from Raman microscopy and energy-dispersive spectroscopy. We observe that (i) calcifications cluster into physiologically relevant groups reflecting tissue type and local malignancy; (ii) carbonate content exhibits substantial intratumor heterogeneity; (iii) trace metals including zinc, iron, and aluminum are enhanced in malignant-localized calcifications; and (iv) the lipid-to-protein ratio within calcifications is lower in patients with poor composite outcome, suggesting that there is potential clinical value in expanding research on calcification diagnostic metrics to include "mineral-entrapped"organic matrix. © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. |
| Keywords: | breast cancer; breast; pathology; breast neoplasms; breast tumor; diagnosis; bone; clinical research; diseases; carbonic acid; carbonates; breast diseases; breast disease; trace elements; calcinosis; cancer patients; mammographic; breast pathology; humans; human; female; condition; energy dispersive spectroscopy; biomineralization; phosphate minerals; biogenics; breast microcalcifications; carbonate content; metal content; micro-calcification[mc] |
| Journal Title: | Science Advances |
| Volume: | 9 |
| Issue: | 8 |
| ISSN: | 2375-2548 |
| Publisher: | Amer Assoc Advancement Science |
| Date Published: | 2023-02-24 |
| Start Page: | eade3152 |
| Language: | English |
| DOI: | 10.1126/sciadv.ade3152 |
| PUBMED: | 36812311 |
| PROVIDER: | scopus |
| PMCID: | PMC9946357 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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