Management of recurrent well-differentiated thyroid carcinoma in the neck: A comprehensive review Review
| Authors: | Cavalheiro, B. G.; Shah, J. P.; Randolph, G. W.; Medina, J. E.; Tufano, R. P.; Zafereo, M.; Hartl, D. M.; Nixon, I. J.; Guntinas-Lichius, O.; Vander Poorten, V.; López, F.; Khafif, A. H.; Owen, R. P.; Shaha, A.; Rodrigo, J. P.; Rinaldo, A.; Mäkitie, A. A.; Silver, C. E.; Sanabria, A.; Kowalski, L. P.; Ferlito, A. |
| Review Title: | Management of recurrent well-differentiated thyroid carcinoma in the neck: A comprehensive review |
| Abstract: | Surgery has been historically the preferred primary treatment for patients with well-differentiated thyroid carcinoma and for selected locoregional recurrences. Adjuvant therapy with radioactive iodine is typically recommended for patients with an intermediate to high risk of recurrence. Despite these treatments, locally advanced disease and locoregional relapses are not infrequent. These patients have a prolonged overall survival that may result in long periods of active disease and the possibility of requiring subsequent treatments. Recently, many new options have emerged as salvage therapies. This review offers a comprehensive discussion and considerations regarding surgery, active surveillance, radioactive iodine therapy, ultrasonography-guided percutaneous ablation, external beam radiotherapy, and systemic therapy for well-differentiated thyroid cancer based on relevant publications and current reference guidelines. We feel that the surgical member of the thyroid cancer management team is empowered by being aware and facile with all management options. © 2023 by the authors. |
| Keywords: | cancer survival; overall survival; disease course; review; cancer localization; cancer recurrence; neck dissection; cancer risk; systemic therapy; cancer radiotherapy; neoadjuvant therapy; metastasis; radiotherapy; recurrence; practice guideline; radioactive iodine; surgery; clinical decision making; cancer epidemiology; external beam radiotherapy; radiofrequency ablation; thyroid surgery; differentiated thyroid cancer; molecular targeted therapy; papillary thyroid cancer; thyroid neoplasm; cancer prognosis; human |
| Journal Title: | Cancers |
| Volume: | 15 |
| Issue: | 3 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2023-02-01 |
| Start Page: | 923 |
| Language: | English |
| DOI: | 10.3390/cancers15030923 |
| PROVIDER: | scopus |
| PMCID: | PMC9913047 |
| PUBMED: | 36765880 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 March 2023 -- Source: Scopus |
