Radiochemical quality control methods for Radium-223 and Thorium-227 radiotherapies Journal Article


Authors: Hasson, A.; Jiang, W.; Benabdallah, N.; Lu, P.; Longtine, M. S.; Beattie, B. J.; Summer, L.; Zhang, H.; Wahl, R. L.; Abou, D. S.; Thorek, D. L. J.
Article Title: Radiochemical quality control methods for Radium-223 and Thorium-227 radiotherapies
Abstract: Background: The majority of radiopharmaceuticals for use in disease detection and targeted treatment undergo a single radioactive transition (decay) to reach a stable ground state. Complex emitters, which produce a series of daughter radionuclides, are emerging as novel radiopharmaceuticals. The need for validation of chemical and radiopurity with such agents using common quality control instrumentation is an area of active investigation. Here, we demonstrate novel methods to characterize 227Th and 223Ra. Materials and Methods: A radio-TLC scanner and a c-counter, two common and widely accessible technologies, as well as a solid-state a-particle spectral imaging camera were evaluated for their ability to characterize and distinguish 227Th and 223Ra. We verified these results through purity evaluation of a novel 227Th-labeled protein construct. Results: The c-counter and a-camera distinguished 227Th from 223Ra, enabling rapid and quantitative determination of radionuclidic purity. The radio-TLC showed limited ability to describe purity, although use under a-particle-specific settings enhanced resolution. All three methods were able to distinguish a pure from impure 227Th-labeled protein. Conclusions: The presented quality control evaluation for 227Th and 223Ra on three different instruments can be applied to both research and clinical settings as new alpha particle therapies are developed. a Mary Ann Liebert, Inc.
Keywords: radiopharmaceuticals; quality control; chemistry; radiopharmaceutical agent; radioisotope; radioisotopes; radium; radium-223; humans; human; thorium; a particle therapy; c counter; radio-thin layer chromatography; thorium-227
Journal Title: Cancer Biotherapy and Radiopharmaceuticals
Volume: 38
Issue: 1
ISSN: 1084-9785
Publisher: Mary Ann Liebert, Inc  
Date Published: 2023-02-01
Start Page: 15
End Page: 25
Language: English
DOI: 10.1089/cbr.2022.0023
PUBMED: 36149725
PROVIDER: scopus
PMCID: PMC9940811
DOI/URL:
Notes: Article -- Export Date: 1 March 2023 -- Source: Scopus
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  1. Bradley Beattie
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