Monitoring the biodistribution of radiolabeled therapeutics in mice Journal Article
| Authors: | Fung, E. K.; Zanzonico, P. B. |
| Article Title: | Monitoring the biodistribution of radiolabeled therapeutics in mice |
| Abstract: | Radiopharmaceutical therapy is a rapidly growing field for the treatment of cancer due to its high specificity and ability to target individual affected cells. A key component of the pre-clinical development of a new therapeutic radiopharmaceutical is the determination of its time-dependent distribution in tumors, normal tissues, and the whole body in mouse tumor models. Here, we provide an overview of the available instrumentation for the novice in radiation measurement. We also detail the methodology for assessing distribution and kinetics of a radiopharmaceutical and calculating radiation absorbed dose in mice using a gamma counter or a PET or SPECT camera. © 2023 Elsevier Inc. |
| Keywords: | dosimetry; pet; biodistribution; spect; radiopharmaceutical therapy; preclinical; theranostic; gamma counter; radiation absorbed dose |
| Journal Title: | Methods in Cell Biology |
| Volume: | 180 |
| ISSN: | 0091-679X |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2023-01-01 |
| Start Page: | 93 |
| End Page: | 111 |
| Language: | English |
| DOI: | 10.1016/bs.mcb.2023.02.012 |
| PROVIDER: | scopus |
| PUBMED: | 37890935 |
| DOI/URL: | |
| Notes: | Chapter 8 in "Radiation Oncology and Radiotherapy Part C" (ISBN: 978-0-323-99007-3) -- Source: Scopus |
