Synapse - Sustained minimal residual disease negativity in multiple myeloma is associated with stool butyrate and healthier plant-based diets

Sustained minimal residual disease negativity in multiple myeloma is associated with stool butyrate and healthier plant-based diets Journal Article

Authors:	Shah, U. A.; Maclachlan, K. H.; Derkach, A.; Salcedo, M.; Barnett, K.; Caple, J.; Blaslov, J.; Tran, L.; Ciardiello, A.; Burge, M.; Shekarkhand, T.; Adintori, P.; Cross, J.; Pianko, M. J.; Hosszu, K.; McAvoy, D.; Mailankody, S.; Korde, N.; Hultcrantz, M.; Hassoun, H.; Tan, C. R.; Lu, S. X.; Patel, D.; Diamond, B.; Shah, G.; Scordo, M.; Lahoud, O.; Chung, D. J.; Landau, H.; Usmani, S. Z.; Giralt, S.; Taur, Y.; Landgren, C. O.; Block, G.; Block, T.; Peled, J. U.; van den Brink, M. R. M.; Lesokhin, A. M.
Article Title:	Sustained minimal residual disease negativity in multiple myeloma is associated with stool butyrate and healthier plant-based diets
Abstract:	Purpose: Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple mye-loma outcomes.Experimental Design: We examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography-mass spectrometry), and the stool micro-biome (via 16S sequencing -a-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food fre-quency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P< 0.05 considered significant. Results: At 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P= 0.025), and a-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxi-dant effects, correlated with stool butyrate concentration (antho-cyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02). Conclusions: This is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.
Keywords:	intestinal microbiota
Journal Title:	Clinical Cancer Research
Volume:	28
Issue:	23
ISSN:	1078-0432
Publisher:	American Association for Cancer Research
Date Published:	2022-12-01
Start Page:	5149
End Page:	5155
Language:	English
ACCESSION:	WOS:000892828400001
DOI:	10.1158/1078-0432.Ccr-22-0723
PROVIDER:	wos
PMCID:	PMC9722533
PUBMED:	36170461
Notes:	Article -- Source: Wos