Targeting the immune microenvironment in mantle cell lymphoma: Implications for current and emerging therapies Review
| Authors: | Qualls, D.; Kumar, A.; Epstein-Peterson, Z. D. |
| Review Title: | Targeting the immune microenvironment in mantle cell lymphoma: Implications for current and emerging therapies |
| Abstract: | Mantle cell lymphoma (MCL) is a morphologically and phenotypically heterogeneous subtype of non-Hodgkin lymphoma, and has historically been associated with poor outcomes. However, recent advances in our understanding of this disease have yielded new targeted and immune-based therapies with promising activity. Immune-based therapies such as monoclonal antibodies, immunomodulators, and CAR T cells have significantly improved outcomes and are now standard of care in MCL. In this review, we describe our current understanding of the immune microenvironment of MCL, discuss current immunotherapeutic approaches, and highlight promising novel immune-based therapies and combination therapies that may further improve outcomes for patients with MCL. © 2022 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; cancer survival; treatment response; review; multimodality cancer therapy; antineoplastic agents; disease free survival; combined modality therapy; outcome assessment; antineoplastic agent; cell proliferation; mantle cell lymphoma; cancer resistance; immunotherapy; cancer vaccine; allogeneic hematopoietic stem cell transplantation; immunomodulating agent; microenvironment; lymphoma, mantle-cell; tumor microenvironment; immunomodulators; cd20 antibody; immune checkpoint inhibitor; cancer prognosis; cellular therapy; humans; human; antineoplastic monoclonal antibody; chimeric antigen receptor t-cell immunotherapy |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 63 |
| Issue: | 11 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2022-01-01 |
| Start Page: | 2515 |
| End Page: | 2527 |
| Language: | English |
| DOI: | 10.1080/10428194.2022.2086244 |
| PUBMED: | 35704674 |
| PROVIDER: | scopus |
| PMCID: | PMC9741766 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2022 -- Source: Scopus |
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