Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies Journal Article
| Authors: | Park, J. A.; Cheung, N. K. V. |
| Article Title: | Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies |
| Abstract: | Immune checkpoint inhibitors (ICI) have shown great promise in a wide spectrum of adult solid and hematological malignancies, achieving objective tumor responses and prolonging survival. However, there is limited clinical success amongst pediatric patients. In this review, we summarize the current understanding of ICI and present an up-to-date overview of recent and ongoing clinical trials of ICI in pediatric malignancies. In addition, we will discuss immunologic and clinical difficulties in this young population, as well as future prospects for combination of ICI with other immune-based and conventional treatments. © 2017 Elsevier Ltd |
| Keywords: | immunotherapy; immune checkpoint inhibitor; cytotoxic t lymphocyte antigen-4 (ctla-4); programmed death receptor-1 (pd-1); programmed death-ligand 1 (pd-l1) |
| Journal Title: | Cancer Treatment Reviews |
| Volume: | 58 |
| ISSN: | 0305-7372 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-07-01 |
| Start Page: | 22 |
| End Page: | 33 |
| Language: | English |
| DOI: | 10.1016/j.ctrv.2017.05.006 |
| PROVIDER: | scopus |
| PUBMED: | 28622628 |
| PMCID: | PMC5524462 |
| DOI/URL: | |
| Notes: | Erratum issued, see DOI: 10.1016/j.ctrv.2017.09.007 -- Review -- Export Date: 3 July 2017 -- Source: Scopus |
