Novel approaches to immunotherapy for B-cell malignancies Journal Article
| Author: | Brentjens, R. J. |
| Article Title: | Novel approaches to immunotherapy for B-cell malignancies |
| Abstract: | Immunotherapy for cancer refers to a wide array of novel therapeutic interventions that harness the immune system to target and eradicate malignant cells in the host. Advances in the understanding of how tumor cells evade host immune detection, coupled with improved gene transduction technologies, have enabled investigators to propose and test novel immune-based therapies for B-cell malignancies. As a result, more immunogenic vaccination strategies, able to elicit immune responses to otherwise poorly immunogenic tumor antigens, are being tested in early clinical trials. Furthermore, with the development of efficient T-cell transduction methodologies, investigators are able to generate autologous antitumor T-cell responses through the introduction of chimeric antigen receptors able to target tumor antigens. However, whether the promising preclinical and phase I clinical data presented here will ultimately translate into improved survival of patients with B-cell malignancies remains largely unknown. Copyright © 2004 by Current Science Inc. |
| Keywords: | cancer survival; unclassified drug; clinical trial; nonhuman; clinical trials as topic; cancer patient; methodology; t lymphocyte; dendritic cell vaccine; cancer immunotherapy; immune system; multiple myeloma; cohort studies; granulocyte macrophage colony stimulating factor; protein; tumor antigen; acute lymphoblastic leukemia; b lymphocyte; genetic transduction; monoclonal antibody; b cell lymphoma; lymphoma, b-cell; t lymphocyte receptor; dendritic cells; nonhodgkin lymphoma; clinical study; immune response; immunotherapy; antigens, neoplasm; cancer vaccine; cancer vaccines; minimal residual disease; immunogenicity; cancer cell; vaccination; data analysis; tumor cell; target cell; dna vaccine; immunological adjuvant; tumor cell vaccine; chronic lymphatic leukemia; lymphocyte antigen receptor; single chain fragment variable antibody; vaccine; host; immunodetection; leukemia, b-cell; humans; human; article; 19 zl |
| Journal Title: | Current Oncology Reports |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2004-10-01 |
| Start Page: | 339 |
| End Page: | 347 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15291974 |
| DOI: | 10.1007/s11912-004-0059-5 |
| DOI/URL: | |
| Notes: | Curr. Oncol. Rep. -- Cited By (since 1996):3 -- Export Date: 16 June 2014 -- CODEN: CORUA C2 - 15291974 -- Source: Scopus |
