The pleiotropic roles of cGAS-STING signaling in the tumor microenvironment Review
| Authors: | Li, J.; Bakhoum, S. F. |
| Review Title: | The pleiotropic roles of cGAS-STING signaling in the tumor microenvironment |
| Abstract: | Cytosolic DNA is prevalent in cells constituting the tumor microenvironment (TME) and can activate the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway. The initiation, transmission, and execution of the cGAS-STING pathway can take place among different cell types within the TME and thus cGAS-STING may play opposing roles in driving tumor progression in addition to its tumor cell-intrinsic role. Herein, we review recent advances in the cGAS-STING field with a focus on its crosstalk with other signaling pathways in the TME. Future efforts to depict a more detailed picture of the roles of cGAS-STING signaling in the TME will help design a better cancer treatment regime by targeting the cGAS-STING pathway more precisely. © The Author(s) (2022). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, CEMCS, CAS. |
| Keywords: | signal transduction; genetics; metabolism; membrane proteins; membrane protein; innate immunity; immunity, innate; immunity; cytosol; nucleotidyltransferase; tumor microenvironment; nucleotidyltransferases; dna sensing; the tumor microenvironment |
| Journal Title: | Journal of Molecular Cell Biology |
| Volume: | 14 |
| Issue: | 4 |
| ISSN: | 1674-2788 |
| Publisher: | Oxford University Press |
| Date Published: | 2022-04-01 |
| Start Page: | mjac019 |
| Language: | English |
| DOI: | 10.1093/jmcb/mjac019 |
| PUBMED: | 35325182 |
| PROVIDER: | scopus |
| PMCID: | PMC9354322 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 September 2022 -- Source: Scopus |
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