Expanding the role of STING in cellular homeostasis and transformation Editorial


Authors: Li, J.; Bakhoum, S. F.
Title: Expanding the role of STING in cellular homeostasis and transformation
Abstract: The cytosolic DNA-sensing cGAS–STING pathway was originally characterized as a key innate immune mediator responsible for the induction of antiviral genes in response to foreign DNA species in the cytosol. Mounting evidence, however, points to a complex role for cGAS and STING in cancer. Two recent reports, by Ranoa et al. (Cancer Research, 2018;https://doi.org/10.1158/0008-5472.CAN-18-1972) and Nassour et al. (Nature 2019;565:659–663), dissect the function of this pathway during the early steps of cellular transformation and shed light on the complexity and context-dependence of cGAS–STING signaling in cancer. © 2019 Elsevier Inc.
Journal Title: Trends in Cancer
Volume: 5
Issue: 4
ISSN: 2405-8025
Publisher: Cell Press  
Date Published: 2019-04-01
Start Page: 195
End Page: 197
Language: English
DOI: 10.1016/j.trecan.2019.02.001
PROVIDER: scopus
PUBMED: 30961826
DOI/URL:
Notes: Source: Scopus
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  1. Samuel F Bakhoum
    42 Bakhoum
  2. Jun Li
    2 Li