The cytosolic DNA-sensing cGAS–STING pathway in cancer Review
| Authors: | Kwon, J.; Bakhoum, S. F. |
| Review Title: | The cytosolic DNA-sensing cGAS–STING pathway in cancer |
| Abstract: | The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. The cGAS–STING pathway was discovered as an important DNA-sensing machinery in innate immunity and viral defense. Recent advances have now expanded the roles of cGAS–STING to cancer. Highly aggressive, unstable tumors have evolved to co-opt this program to drive tumorigenic behaviors. In this review, we discuss the link between the cGAS–STING DNA-sensing pathway and antitumor immunity as well as cancer progression, genomic instability, the tumor microenvironment, and pharmacologic strategies for cancer therapy. Significance: The cGAS–STING pathway is an evolutionarily conserved defense mechanism against viral infections. Given its role in activating immune surveillance, it has been assumed that this pathway primarily functions as a tumor suppressor. Yet, mounting evidence now suggests that depending on the context, cGAS–STING signaling can also have tumor and metastasis-promoting functions, and its chronic activation can paradoxically induce an immune-suppressive tumor microenvironment. © 2019 American Association for Cancer Research. |
| Journal Title: | Cancer Discovery |
| Volume: | 10 |
| Issue: | 1 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2020-01-01 |
| Start Page: | 26 |
| End Page: | 39 |
| Language: | English |
| DOI: | 10.1158/2159-8290.Cd-19-0761 |
| PUBMED: | 31852718 |
| PROVIDER: | scopus |
| PMCID: | PMC7151642 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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