De novo neuroendocrine features in prostate cancer Review


Authors: Abdulfatah, E.; Fine, S. W.; Lotan, T. L.; Mehra, R.
Review Title: De novo neuroendocrine features in prostate cancer
Abstract: Neuroendocrine tumors of the prostate are rare and encompass a group of entities that are classified based on a combination of morphological and immunohistochemical features. Despite the 2016 World Health Organization classification of prostatic neuroendocrine tumors, variants have been reported that do not fit well in the categorization scheme. While the majority of these tumors arise in the setting of castration-resistant prostate cancer (postandrogen deprivation therapy), de novo cases may occur. In this review, we highlight the most significant pathological and immunohistochemical features, emerging biomarkers, and molecular features of such tumors. © 2022
Keywords: prostate; neuroendocrine; transdifferentiation; de novo; proproliferative
Journal Title: Human Pathology
Volume: 127
ISSN: 0046-8177
Publisher: Elsevier Inc.  
Date Published: 2022-09-01
Start Page: 112
End Page: 122
Language: English
DOI: 10.1016/j.humpath.2022.07.002
PUBMED: 35810832
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 September 2022 -- Source: Scopus
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  1. Samson W Fine
    462 Fine