Primary well-differentiated neuroendocrine tumor/carcinoid of the prostate: Case report and review of literature Journal Article
| Authors: | Alhamar, M.; Sethi, S.; Reuter, V. E.; Fine, S. W. |
| Article Title: | Primary well-differentiated neuroendocrine tumor/carcinoid of the prostate: Case report and review of literature |
| Abstract: | Primary well-differentiated neuroendocrine tumor (WDNT)/carcinoid of the genitourinary tract is rare. Many WDNT reported in the prostate gland have been seen in close association with conventional prostatic adenocarcinoma and/or label for prostate-specific immunohistochemical markers and are best considered prostatic adenocarcinomas with “carcinoid-like” features. We present a case of primary WDNT/carcinoid incidentally detected in a 67-year-old man who underwent radical prostatectomy for Grade group 2 prostatic adenocarcinoma. Morphologically, the neuroendocrine (NE) lesion appeared distinct from the prostatic adenocarcinoma, labeled for NE markers, was negative for prostatic markers (NKX3.1, PSA, and ERG), and showed an overall low Ki-67 proliferation index (<1%). Follow-up was uneventful with no evidence of residual disease or metastasis. © The Author(s) 2024. |
| Keywords: | clinical article; human tissue; aged; case report; hypertension; nuclear magnetic resonance imaging; lymph node dissection; adenocarcinoma; metabolism; pathology; tumor marker; neuroendocrine tumor; prostate cancer; gleason score; prostatic neoplasms; prostate; incidental findings; prostatectomy; prostate tumor; diagnosis; surgery; radical prostatectomy; carcinoid; invasive carcinoma; prostate adenocarcinoma; incidental finding; hypercholesterolemia; non insulin dependent diabetes mellitus; carcinoid tumor; neuroendocrine tumors; neuroendocrine; medical history; prostatic adenocarcinoma; transurethral biopsy; high throughput sequencing; proliferation index; humans; human; male; article; biomarkers, tumor; robot-assisted prostatectomy; prostate imaging reporting and data system; prostate carcinoid; prostate well differentiated neuroendocrine tumor |
| Journal Title: | International Journal of Surgical Pathology |
| Volume: | 32 |
| Issue: | 7 |
| ISSN: | 1066-8969 |
| Publisher: | Sage Publications |
| Date Published: | 2024-10-01 |
| Start Page: | 1374 |
| End Page: | 1378 |
| Language: | English |
| DOI: | 10.1177/10668969241228297 |
| PUBMED: | 38303155 |
| PROVIDER: | scopus |
| PMCID: | PMC11808340 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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