Primary prostatic carcinoma with de novo diffuse neuroendocrine differentiation Journal Article

   


Authors: Galea, L. A.; Mow, C.; Fine, S. W.; Manohar, P.
Article Title: Primary prostatic carcinoma with de novo diffuse neuroendocrine differentiation
Abstract: The 2016 World Health Organization classification of prostate cancer with neuroendocrine (NE) differentiation includes NE cells in usual prostate cancer, adenocarcinoma with Paneth cell-like NE differentiation, well-differentiated NE tumor (carcinoid), small cell NE carcinoma, and large cell NE carcinoma. In this article, we report a rare case of primary prostatic carcinoma with de novo diffuse NE differentiation presenting with bilateral hydronephrosis in a 79-year-old man. This case did not fit into any of the existing classifications. The clinical, radiological, morphological, and immunohistochemical findings and response to androgen deprivation therapy (ADT) are presented. The proposed pathogenesis of NE differentiation via transdifferentiation from conventional prostatic adenocarcinoma whereby genomic alterations, coupled with ADT can induce lineage plasticity resulting in NE differentiation is described. © The Author(s) 2021.
Keywords: aged; genetics; case report; adenocarcinoma; cell differentiation; pathology; physiology; prostatic neoplasms; prostate tumor; androgen antagonists; carcinoma; antiandrogen; large cell carcinoma; androgen deprivation therapy; prostate carcinoma; carcinoma, neuroendocrine; carcinoma, large cell; neuroendocrine differentiation; transdifferentiation; humans; human; male; amphicrine carcinoma
Journal Title: International Journal of Surgical Pathology
Volume: 30
Issue: 2
ISSN: 1066-8969
Publisher: Sage Publications  
Date Published: 2022-04-01
Start Page: 232
End Page: 236
Language: English
DOI: 10.1177/10668969211035844
PUBMED: 34338584
PROVIDER: scopus
PMCID: PMC9887995
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111890641&doi=10.1177%2f10668969211035844&partnerID=40&md5=1bba8d77feaef7113559a7dae16d1d00
Notes: Article -- Export Date: 1 April 2022 -- Source: Scopus
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MSK Authors
  1. Samson W Fine
    466 Fine
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