Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer Review
| Authors: | Myer, N. M.; Shitara, K.; Chung, H. C.; Lordick, F.; Kelly, R. J.; Szabo, Z.; Cao, Z. A.; Leong, S.; Ilson, D. H.; Weichert, W. |
| Review Title: | Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer |
| Abstract: | Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer. © 2022, Merck & Co., Inc., Kenilworth, NJ, USA and its affiliates under exclusive license to Springer-Verlag GmbH Germany, part of Springer Nature. |
| Keywords: | biomarkers; metabolism; tumor marker; microsatellite instability; stomach neoplasms; stomach tumor; gastric cancer; programmed death 1 ligand 1; humans; prognosis; human; biomarkers, tumor; b7-h1 antigen; tumor mutational burden; programmed death ligand 1 |
| Journal Title: | Journal of Cancer Research and Clinical Oncology |
| Volume: | 148 |
| Issue: | 8 |
| ISSN: | 0171-5216 |
| Publisher: | Springer |
| Date Published: | 2022-08-01 |
| Start Page: | 2023 |
| End Page: | 2043 |
| Language: | English |
| DOI: | 10.1007/s00432-021-03902-1 |
| PUBMED: | 35551464 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2022 -- Source: Scopus |
