Approach to resectable gastric cancer: Evolving paradigm of neoadjuvant and adjuvant treatment Review

  


Authors: Lumish, M. A.; Ku, G. Y.
Review Title: Approach to resectable gastric cancer: Evolving paradigm of neoadjuvant and adjuvant treatment
Abstract: Recent therapeutic advances have prolonged survival in patients with metastatic gastric cancer, though the prognosis for patients with locally advanced resectable gastric cancer remains poor. Long-term survival after resection of locally advanced gastric adenocarcinoma is dependent on early eradication of micrometastatic disease and optimal surgical resection. Preoperative therapy with a docetaxel-containing three-drug regimen has recently been shown to be superior to an anthracycline-containing three-drug regimen or two-drug therapy with a fluoropyrimidine and platinum. Chemoradiation is not essential and is reserved for patients with suboptimal resection. Emerging research strategies include introduction of pre- and postoperative checkpoint blockade and biomarker-directed therapy. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: cancer surgery; postoperative period; cancer adjuvant therapy; chemotherapy, adjuvant; neoadjuvant therapy; positron emission tomography; antineoplastic agent; adenocarcinoma; antineoplastic combined chemotherapy protocols; practice guideline; pathology; patient care; preoperative period; adjuvant chemotherapy; stomach cancer; neoadjuvant chemotherapy; stomach neoplasms; chemoradiation; stomach tumor; gastric cancer; molecularly targeted therapy; perioperative therapy; immune checkpoint inhibitor; adjuvant chemoradiotherapy; chemoradiotherapy, adjuvant; humans; human; article; circulating tumor dna; immune checkpoint inhibition
Journal Title: Current Treatment Options in Oncology
Volume: 23
Issue: 7
ISSN: 1527-2729
Publisher: Springer  
Date Published: 2022-07-01
Start Page: 1044
End Page: 1058
Language: English
DOI: 10.1007/s11864-021-00917-1
PUBMED: 35524838
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130026656&doi=10.1007%2fs11864-021-00917-1&partnerID=40&md5=e502c6bedfcd60241497d50a997e713e
Notes: Article -- Export Date: 1 July 2022 -- Source: Scopus
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MSK Authors
  1. Geoffrey Yuyat Ku
    236 Ku
  2. Melissa Amy Lumish
    39 Lumish
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